Horse Diagnostic Testing
HYPP – Hyperkalemic Periodic Paralysis (HYPP) is an inherited muscular disease found predominantly in animals that are of Quarter Horse descent. The disease is inherited in a dominant manner. Horses with HYPP can exhibit episodes of muscle tremors, generalized or localized shaking, trembling and weakness. The episodes can range from almost undetectable tremors to sudden paralysis, collapse and cardiac arrest or respiratory failure in the most severe cases. Testing for HYPP is of great value as symptoms can be lessened or even eliminated through diet and management practices. Since the penetrability and severity of HYPP is highly variable, testing is recommended for diagnostic, treatment and breeding purposes.
Lethal White Foal Syndrome – Lethal White Foal Syndrome (LWFS) is a recessively inherited lethal abnormality occurring in horse breeds with white spotting patterns. Over 90% of carriers of this genetic condition have the Overo pattern, but it has been found in non-overo animals. Breeds that may be affected include Paint, Thoroughbreds, Miniature Horses and Quarter Horses. Affected foals are born completely white; the disease is characterized by congenital intestinal deformity caused by a lack of submucosal and myenteric ganglia from the distal small intestine to the large intestine. This results in painful blockage of the large colon and fecal compaction. All foals born with the condition die within 2 weeks of birth. Testing white spotted animals for carrier status of LWFS may be used to prevent mating of two carriers, and the possible birth of an affected foal.
Leopard Complex – A polymorphism found in Appaloosas, is caused by the presence of a 1378 bp insertion in the Transient Receptor Potential Cation Channel Subfamily M, member 1 gene (TRPM1) that is responsible for leopard patterning in the heterozygous and homozygous form and causes night blindness when homozygous. Although the leopard patterning is considered highly desirable, and is expressed in both heterozygous and homozygous animals, CSNB results in the impairment of vision in dark conditions. This condition is not progressive, and foals with CSNB exhibit the condition from birth. The test is suitable for DNA derived from any sample type, for example blood, hair follicles, tissue etc.
Please contact us for additional information regarding sample requirements and submission.